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Sunday, April 19, 2020 | History

5 edition of Gene profiling in drug design found in the catalog.

Gene profiling in drug design

Gene profiling in drug design

  • 310 Want to read
  • 18 Currently reading

Published by Taylor & Francis in Boca Raton .
Written in English

    Subjects:
  • Pharmacogenetics,
  • Drugs -- Design,
  • Drug Design,
  • Gene Expression Profiling,
  • Gene Expression Regulation,
  • Gene Therapy -- methods,
  • MicroRNAs -- therapeutic use

  • Edition Notes

    Statementeditors, Brett A. Lidbury and Suresh Mahalingam.
    ContributionsLidbury, Brett A., Mahalingam, Suresh.
    Classifications
    LC ClassificationsRM301.3.G45 .G458 2008
    The Physical Object
    Paginationp. ;
    ID Numbers
    Open LibraryOL18534524M
    ISBN 109780849337338
    LC Control Number2008013724

      Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, pharmacogenetic, and toxicogenomic toolboxes, four promising and rapidly growing areas of genomics research that have begun opening the door to personalized medicine solutions. Study of a drug's mechanism of action by gene expression profiling.


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Gene profiling in drug design Download PDF EPUB FB2

Gene-profiling technologies and the concept of individualized medicine are leading to the development of drugs with enhanced specificity. This promises to lead to more effective treatment of diseases with reduced risk of side effects.

Gene Profiling in Drug Design provides insights from leaders in the pure sciences, biotechnology, and other. Gene profiling in drug design.

by Brett A. Lidbury and Suresh Mahalingam. CRC / Taylor & Francis pages. A perspective on the future clinical impact of genetic diagnosis and gene-based drug therapies for patient health / Julian W. Tang --Virally encoded microRNA (miRNA): candidates for gene silencing / Ralph A.

Tripp [and others] --Development of gene profile-responsive antisense agents / Sergei A. Kazakov and Brian H. Johnston --Gene profiles in. Get this from a library. Gene profiles in drug design. [Brett A Lidbury; Suresh Mahalingam;] -- Featuring contributions from leaders in the pharmaceutical industry, "Gene Profiles in Drug Design" explores the processes and technologies that yield gene profile based drugs.

Each chapter focuses. A drug that interferes with this receptor may prevent or treat breast cancer. In developing a drug, one may perform gene expression profiling experiments to help assess the drug's toxicity, perhaps by looking for Gene profiling in drug design book levels in the expression of cytochrome P genes.

DOI link for Gene Profiles in Drug Design. Gene Profiles in Drug Design book. Edited By Brett A. Lidbury, Suresh Mahalingam. Edition 1st Edition. First Published eBook Published 10 July Gene-profiling technologies and the concept of individualized medicine are leading to the development of drugs with enhanced : Brett A.

Lidbury, Suresh Mahalingam. Gene expression profiling has helped in the better understanding of breast cancer biology. Among the applications of gene profiling in breast cancer are the subclassification of breast cancer, disease prognosis, prediction of response to therapy, and specialization of therapy based on the hos.

Breast cancer is composed of multiple subtypes Author: Katerina Pierouli, Thanasis Mitsis, Eleni Papakonstantinou, Dimitrios Vlachakis.

This chapter discusses the camptothecins for drug design, cancer cell death and gene targeting. Camptothecin (CPT) was originally discovered in the early s, by Wani's group at the NCI, from an extract of the bark of the Chinese tree Camptotheca acuminata – a common deciduous tree used for ages in traditional Chinese medicine.

Gene profiling can also investigate the effect of drug-like molecules on cellular response. You could identify the gene markers of drug metabolism, or determine whether cells express genes known to be involved in response to toxic environments when exposed to the drug [4].

Gene profiling can also be used as a diagnostic tool. The ultimate goal of gene expression profiling is to help the oncologist design an individualized treatment plan with maximum benefit and minimum toxicity through the use of predictive markers.

Unlike the numerous prognostic indicators being developed as described above, there are very few models predictive for therapy that are by: Clinical Trials of Precision Medicine through Molecular Profiling: Focus on Breast Cancer.

such as gene-expression profiling and next-generation sequencing, are expanding our knowledge of the molecular landscapes of several cancer types. and (6) adaptive design trials. This article provides an overview of the challenges for clinical Cited by: Title: Monitoring Therapy with Gene Expression Profiling Reveals Physiological Differences in Drug Action VOLUME: Gene profiling in drug design book ISSUE: 16 Author(s):S.

Wolfl, A. Burchert and T. Kroll Affiliation:AG Molekularbiologie, Klinik für Innere Medizin II, Klinikum der Friedrich-Schiller-Universität Jena, Erlanger AlleeJena, Germany. Keywords:gene expression profiling, tyrosine kinase inhibitor Cited by: 4. Structure- and Ligand-Based Approaches.

Author: Kenneth M. Merz, Jr,Dagmar Ringe,Charles H. Reynolds; Publisher: Cambridge University Press ISBN: Category: Medical Page: View: DOWNLOAD NOW» This book provides a complete snapshot of various experimental approaches to structure-based and ligand-based drug design and is illustrated with more than images.

Title: Gene Expression Profiling and its Practice in Drug Development VOLUME: 8 ISSUE: 4 Author(s): Murty V. Chengalvala, Vargheese M. Chennathukuzhi, Cited by: Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical RD and reduce drug candidate attrition and failure.

By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker.

Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates.

This valuable resource explores physiochemical properties, including solubility and permeability, before. ORIGINAL ARTICLE Integrating Clinical Phenotype and Gene Expression Data to Prioritize Novel Drug Uses H Paik1,2, B Chen1,2, M Sirota1,2, D Hadley1,2 and AJ Butte1,2* Drug repositioning has been based largely on genomic signatures of drugs and by: 4.

Molecular docking has always been and will be on the forefront of developments in the eminent field of drug design and medicinal chemistry. At the early days, drug discovery was based on blackboard drawings and expert intuition. However, as times move on, the amount of available information and overall knowledge base that needs to be analyzed cannot be processed manually.

This, coupled by. Pharmaceutical Perspectives of Cancer Therapeutics presents a comprehensive yet easy-to-follow review of the principles, current progress and state-of-the-art of cancer therapeutics. The complexity of cancer demands an integrated understanding from both cancer biology and pharmaceutical dosage forms and drug delivery in order to warrant a successful therapeutic regimen.

Over the past month, the Food and Drug Administration (FDA) has approved two tests to identify genetic alterations in tumors. The most recent approval, on December 1, is the FoundationOne CDx (F1CDx) genomic test, which can identify cancer-associated alterations in genes and two types of genomic alterations—called genomic signatures—in any type of solid tumor.

Gene set enrichment analysis (GSEA) (also functional enrichment analysis) is a method to identify classes of genes or proteins that are over-represented in a large set of genes or proteins, and may have an association with disease method uses statistical approaches to identify significantly enriched or depleted groups of genes.

The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics.

Rational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often difficult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing affordability of genome-wide next-generation technologies now provides an excellent.

This chapter presents a protocol for using cDNA microarrays to acquire gene expression pro files that characterize anticancer drug sensitivity.

The protocol includes steps for drug exposure, RNA isolation, preparation of fluorescently labeled samples, microarray hybridization, data Cited by: 1. High-throughput technologies of molecular profiling in cancer, such as gene-expression profiling and next-generation sequencing, are expanding our knowledge of the molecular landscapes of several cancer types.

This increasing knowledge coupled with the development of several molecularly targeted agents hold the promise for personalized cancer medicine to be fully realized. Moreover, an Cited by: Current Metabolomics and Systems Biology publishes full-length/mini reviews, original research articles, thematic issues, and technical notes covering all aspects of the recent advancements and applications of Omics technology to systems biology, disease diagnosis, personalized medicine, drug discovery, toxicity, nutrition and food, environmental studies, and functional genomics.

The book "Genomics in Drug Discovery and Development" by D. Semizarov and E. Blomme is the first and the most comprehensive text to combine three exciting and rapidly developing scientific disciplines that enable personalized medicine, namely biomarker research, toxicogenomics, and by: 6.

The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of.

The increase in imaging throughput, new analytical frameworks and high-performance computational resources open new avenues for data-rich phenotypic profiling of small molecules in drug discovery.

A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME).

Drug Design:Discovery, Development and Delivery 1. Drug Design: Discovery, Development and Delivery Dr. Basavaraj K. NanjwadePh.D Associate Professor Department of Pharmaceutics KLE University BELGAUM – E-mail: [email_address] Cell No: 2.

Drug Design 3. Cancer is a global health problem and there is a critical need for new advancements in its management and treatment if we are to meet the projected increase in Cited by: Gene Expression Profiling by Microarrays Clinical Implications Microarray analysis is a highly efficient tool for assessing the expression of a large number of genes simultaneously, and offers a new means of classifying cancer and other diseases.

Gene expression profiling can File Size: KB. Biopharmaceutical Drug Design and Development, Second Edition, furthers the widely successful first edition, published in This new, expanded edition investigates the dozens of new biopharmaceutical drugs that have become available since that time.

Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes 4/5(1). Introduction to the Drug Discovery Process.

The process of drug discovery within the modern scientific context is quite complex, integrating many disciplines, including structural biology, metabolomics, proteomics, and computer science, just to name a process is generally quite tedious and expensive, given the sheer amount of possibilities of drug-to-target interactions in-vivo, and.

Our study design was approved by the medical ethical committee of the Erasmus MC Rotterdam, the Netherlands (MEC ). To evaluate the predictive value of gene expression profiling in relation to tamoxifen treatment in patients with recurrent breast cancer, fresh frozen ER-α–positive (≥ 10 fmol/mg of protein) primary breast tumor tissue specimens of patients with primary operable Cited by: UNC Eshelman School of Pharmacy Pharmacy Lane, CB# Chapel Hill, NC () Directions & Parking Chapel Hill Visitors Bureau.

IOTA participates in the design of novel antiparasitic agents University publishes on methods to improve screening. Dec IOTA scientists review the impact of phenotypic profiling in GBM drug discovery and patient stratification IOTA scientist publishes book chapter on drug targeting for Protein-Protein Interactions.

Jan   Gene expression profiling using microarrays has shown that light regulates more than 30% of the genome in seedlings of Arabidopsis, including more than 26 cellular pathways (Ma et al., ).

In whole seedlings and leaves, microarray analyses have identified many of the genes involved in red- and far-red-light signalling (Tepperman et al Cited by: Impact of Physicochemical Profiling for Rational Approach on Drug Discovery Article in Chemical & pharmaceutical bulletin 61(12) December with 34 Reads How we measure 'reads'.

Find and compare the best bioinformatics software for ligand-based virtual screening. Tools are ranked by the biomedical research community.

Chemical biology & drug design 2 Journal of the american chemical society 2 of RPL26 and microRNAa link Gene expression profiling in the lung and.Gene expression profiling has been used in the dissection of specific oncogenic molecular pathways, including the p53 tumor-suppressor pathway, the APC/β-catenin pathway, and numerous in vitro and in vivo models of angiogenesis and cancer drug resistance.This includes a current and global perspective of drug design, and drug expanded content from 69 chapters to over chapters, this sixth edition of "Burger's Medicinal Chemistry and Drug Discovery" includes more than 50 percent new material.

An entire section has been dedicated to cancer research.